peptide corresponding to a sequence at the C-terminus of human CD45.
亚型:
Rabbit Polyclonal IgG
形态:
液态
保存条件:
保存于-20℃
克隆性:
多克隆
标记物:
无标记(PLlabs可供应生物素、酶、荧光素标记的抗体)
适应物种:
Hu
保质期:
按说明书条件可保存1-2年
抗原来源:
见详细说明资料
目录编号:
PL0402235
级别:
超纯
库存:
大量
供应商:
华拓生物
宿主:
Rabbit
应用范围:
WB: 1:100-500 IHC: 1:500-1000 ICC: 1:500-1000
浓度:
1mg/ml
靶点:
PTPRC/CD45
抗体英文名:
PTPRC/CD45 Antibody
抗体名:
PTPRC/CD45抗体
规格:
0.1ml
PTPRC/CD45 Antibody
Cat#:PL0402235
Isotype:Rabbit Polyclonal IgG
Immunogen:peptide corresponding to a sequence at the C-terminus of human CD45.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
CD45(Cluster of Differentiation 45), also known as PTPRC, LCA or CD45R, is an enzyme that, in humans, is encoded by the PTPRC gene.CD45 is a member of the protein tyrosine phosphatase(PTP) family. CD45 is a major high molecular mass leukocyte cell surface molecule which is also an integral membrane protein tyrosine phosphatase.The cytogenetic location of CD45 is 1q31.3-q32.1. CD45 is especially a prototype for transmembrane protein-tyrosine phosphatase(PTP). Targeted disruption of the CD45 gene leads to enhanced cytokine and interferon receptor-mediated activation of JAKs and STAT proteins. In vitro, CD45 directly dephosphorylates and binds to JAKs. Functionally, CD45 negatively regulates interleukin-3-mediated cellular proliferation, erythropoietin-dependent hematopoiesis, and antiviral responses in vitro and in vivo.