C1r Antibody
Cat#:PL0306880
Isotype:Rabbit Polyclonal IgG
Immunogen:Peptide derived from human C1r.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
The complement component proteins, C1, C3, C4, and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation, and cellular chemotaxis. C1q, together with proenzymes C1r and C1s, yield C1, the first component of the classical pathways of the serum complement system. C1 consists of a calcium dependent trimolecular complex of C1r, C1s and C1q in a 2:2:1 ratio.
Alternate Names:
C1R; C1R_HUMAN; Complement C1r; Complement C1r subcomponent; Complement C1r subcomponent light chain; Complement C1r subcomponent precursor; Complement component 1 r subcomponent; Complement component 1 subcomponent r.
Specificity Reaction:Hu, Mo, Rat, Dog, Pig, Cow, Sheep
Application Notes:WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:100-500 ICC: 1:100-500
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
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