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- 文献和实验
- 技术资料
- 保存条件:
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
6877-32-3
- 规格:
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格: | 10 mM * 1 mL | 产品价格: | ¥1226.0 |
|---|---|---|---|
| 规格: | 1 mg | 产品价格: | ¥662.0 |
| 规格: | 5 mg | 产品价格: | ¥1450.0 |
| 规格: | 10 mg | 产品价格: | ¥2550.0 |
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Corynoxine
CAS No. : 6877-32-3
MCE 国际站:Corynoxine
产品活性:Corynoxine 是一种从 Uncaria rhynchophylla 中分离出的四环羟吲哚生物碱。Corynoxine 是一种天然的自噬增强剂,可通过 Akt/mTOR 途径促进 α-突触核蛋白的清除。
研究领域:Autophagy
作用靶点:Autophagy
In Vitro: Corynoxine (6.25-25 μM; 6-12 h) increases the expression of LC3-II, an autophagy specific marker, in N2a and SH-SY5Y cells in a dose-dependent manner.
Corynoxine (25 μM; 48 h) promotes the degradation of wild type (WT) and mutant (A53T) α-syn in inducible PC12 cells via autophagy induction.
In Vivo: Corynoxine (100-100 mg/kg; oral gavage) exhibits prolongation of the thiopental-induced hypnosis in mice.
Corynoxine (10-100 μM for 12 h) induces autophagy in drosophila.
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文献和实验Rules of siRNA design for RNA interference
) For example, the Tm can be calculated as follows for the siRNA UUCUCCAGCUUCUAAAAUA Tm = 79.8 + 18.5*log10 (0.05) + (58.4 * 31.6/100) + (11.8 * (31.6/100)2 ) - (820/19) Tm = 32.19 There are two siRNA design tools which implement this siRNA design algorithm
UUCUCCAGCUUCUAAAAUA Tm = 79.8 + 18.5*log10 (0.05) + (58.4 * 31.6/100) + (11.8 * (31.6/100)2 ) - (820/19) Tm = 32.19 There are two siRNA design tools which implement this siRNA design algorithm: one is offered by Dharmacon
Rules of siRNA design for RNA interference (RNAi)
)2 ) - (820/Length) For example, the Tm can be calculated as follows for the siRNA UUCUCCAGCUUCUAAAAUA Tm = 79.8 + 18.5*log10(0.05) + (58.4 * 31.6/100) + (11.8 * (31.6/100)2 ) - (820/19) Tm = 32.19 There are two siRNA design tools
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