NRF-1是核基因编码且影响mtDNA的另一重要因子, 他控制着线粒体电子传递链的一些蛋白质的合成。
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1. [provided by RefSeq].
mol wt:55kDa
Other Aliases: nuclear respiratory factor-1; Nrf1; C87038; D6Ertd415e; ALPHA-PAL; alpha palindromic binding protein; locus control region factor 1; NFE2 related factor 1; nuclear factor (erythroid derived 2)-like 1; Nfe2l1_retired; transcription factor 11