PAK5 is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression.
mol wt:79kDa
Other Aliases: Mbt; mushroom bodies tiny; CG18582; Dmel\CG18582; DmMBT; DmPAK2; dPAK2; Mbt; Pak2; Ste20; STE20; Serine/threonine-protein kinase PAK mbt; Protein mushroom bodies tiny; p21-activated kinase-related protein; LD47563p; Ste20 serine/threonine protein kinase homolog; GG19059; GM13449; GE17281; 2900083L08Rik; 6430627N20; MGC117585; Serine/threonine-protein kinase PAK 7; 2900083L08Rik; 6430627N20; MGC117585; Pak5; PAK7; p21-activated kinase 5; P21 protein (Cdc42/Rac)-activated kinase 7