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- AG-CN2-0010-M001
- 2025年07月16日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 英文名：
PMA
- CAS号：
16561-29-8
- 保质期：
随货说明
- 保存条件：
20°C
- 库存：
99
- 供应商：
欣博盛生物
- 规格：
1 mg
PMA产品由Adipogen公司生产，产地是瑞士。该产品货号为AG-CN2-0010-M001，包装规格是1 mg。如需购买该产品，询问折扣价/货期/技术问题，请联系Adipogen授权代理商——欣博盛生物
Description
PMA/TPA is the most commonly-used phorbol ester.
Binds to and activates protein kinase C (PKC) at nM concentrations.
Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16.
Potent mouse skin tumor promoter.
Promoter of inducible NOS (iNOS; NOS II).
Apoptosis inducer.
Potential effective cancer therapeutic agent.
Inhibitor of anti-lipolytic activity of insulin.
PMA treatment stimulates THP-1 cells and generates M0 macrophages (M0).
Product Details
Synonyms PMA; TPA; 12-O-Tetradecanoylphorbol 13-acetate
Product Type Chemical
Properties
Formula
C36H56O8
MW 616.8
Merck Index 14: 7332
CAS 16561-29-8
RTECS QH4377000
Source/Host Chemicals Semisynthetic.
Purity Chemicals ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO (20mg/ml), 100% ethanol (20mg/ml), methanol, ace-tone, ether or dimethylformamide; almost insoluble in aqueous buffers.
Identity Determined by 1H-NMR
Other Product Data
Stock solutions are stable for up to 3 months at -20°C.
InChi Key PHEDXBVPIONUQT-RGYGYFBISA-N
Smiles [H][C@]12[C@]3([H])C=C(CO)C[C@]4(O)C(=O)C(C)=C[C@@]4([H])[C@@]3(O)[C@H](C)[C@@H](OC(=O)CCCCCCCCCCCCC)[C@@]1(OC(C)=O)C2(C)C
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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- 作者
- 内容
- 询问日期
文献和实验- In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1: P.M. Blumberg; Crit. Rev. Toxicol. 8, 153 (1980)
- In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 2: P.M. Blumberg; Crit. Rev. Toxicol. 8, 199 (1981)
- Skin tumor promotion by phorbol esters is a two-stage process: G. Fürstenberger, et al.; PNAS 78, 7722 (1981)
- Phorbol esters as signal transducers and tumor promoters: M. Castagna; Biol. Cell 59, 3 (1987), Review
- Phorbol esters induce nitric oxide synthase activity in rat hepatocytes. Antagonism with the induction elicited by lipopolysaccharide: S. Hortelano, et al.; J. Biol. Chem. 267, 24937 (1992)
- Phorbol ester induces apoptosis in HL-60 promyelocytic leukemia cells but not in HL-60 PET mutant: D.E. Macfarlane & P.S. O'Donnel; Leukemia 7, 1846 (1993)
- Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13- acetate (TPA) in patients with myelocytic leukemia: Preliminary studies on therapeutic efficacy and toxicity: T.H. Zheng, et al.; PNAS 95, 5357 (1998)
- 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced increase in depressed white blood cell counts in patients treated with cytotoxic cancer chemotherapeutic drugs: T.H. Zheng, et al.; PNAS 95, 5362 (1998)
- Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay: L. Saraiva, et al.; Eur. J. Pharmacol. 491, 101 (2004)
- Phorbol 12-myristate 13-acetate inhibits the antilipolytic action of insulin, probably via the activity of protein kinase Cε: J. Nakamura; Eur. J. Pharmacol. 648, 188 (2010)
- Characterization of polarized THP-1 macrophages and polarizing ability of LPS and food compounds: W. Chanput, et al.; Food Funct. 4, 266 (2013)
- M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide: M. Genin, et al.; BMC Cancer 15, 577 (2015)
- The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus: M.E. Lund, et al.; J. Immunol. Methods 430, 64 (2016)
- Vitamin D3 inhibits the proliferation of T helper cells, downregulate CD4+ T cell cytokines and upregulate inhibitory markers: V. Sheikh, et al. Human Immunol. 79, 439 (2018)
- Adults from Kisumu, Kenya have robust γδ T cell responses to Schistosoma mansoni, which are modulated by tuberculosis: T.A. McLaughlin, et al.; PLoS Negl. Trop. Dis. 14, e0008764 (2020)
- Standardized protocols for differentiation of THP-1 cells to macrophages with distinct M(IFNγ+LPS), M(IL-4) and M(IL-10) phenotypes: E.W. Baxter, et al.; J. Immunol. Methods 478, 112721 (2020)
- Paeoniflorin reduces the inflammatory response of THP-1 cells by up‐regulating microRNA-124: D. Huang, et al.; Genes & Genomics 43, 623 (2021)
- Lymphatic dysfunction exacerbates cutaneous tumorigenesis and psoriasis-like skin inflammation through accumulation of inflammatory cytokines: H. Boki, et al.; J. Invest. Dermatol. 142, 1692 (2022)
- IL-17A and IFN-γ are Up-regulated in CD4 and γδ T Cells in Active Behcet's Disease Patients: V. Abbasova, et al.; Immunol. Lett. 242, 37 (2021)
致癌助催剂（promoter）。系从大戟科（Euphorbiaceae）植物巴豆（Croton tiglium）种子搾取获得的巴豆油中所含的促致癌活性成分。也称为TPA（12-0-四癸酰基佛博尔13-乙酸）或PMA（佛博尔豆蔻乙酸）。
Cultivation of Normal Human Epidermal Melanocytes in the Absence of Phorbol Esters
skin, was initially achieved by suppressing the growth of keratinocytes and fibroblasts in epidermal cell suspensions with the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) and the intracellular cyclic adenosine 3’ , 5’ monophosphate (cAMP
T1.1 =26.2 T1.2 =43-26.2=16.8 T2.1 =53-26.2=26.8 T2.2 =44-26.2=17.2 3.计算x2 值 按公式20.12代入 4．查x2 值表求P值 在查表之前应知本题自由度。按x2 检验的自由度v=（行数-1）（列数-1），则该题的自由度v=（2-1）（2-1）=1，查x2 界值表（附表20-1），找到x2 0.001
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