FGH10019,1046045-61-7

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FGH10019

CAS No. : 1046045-61-7

MCE 国际站：FGH10019

产品活性：FGH10019 是一种固醇调节元件结合蛋白 (SREBP) 抑制剂，IC₅₀ 值为 1 μM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Fatty Acid Synthase (FASN)

In Vitro: Treatment of the CHO-K1 cells with analog FGH10019 decreases the percentage of the mature form of SREBP-2 (68 kDa) at lower concentrations than treatment with fatostatin. Densitometric analysis of the gels indicates that the IC₅₀ of analog FGH10019 is approximately 1 μM, which is 5-10 times lower than the IC₅₀ of fatostatin (appr 10 μM).

In Vivo: FGH10019-treated chow is fed at a dose rate calculated to provide about 0.7 mg analog FGH10019 per day, at about 23 mg/kg body weight, to 5-wk-old male ob/ob mice weighing an average of appr 30 g. After 8 wk on the analog 24-treated chow, the mice gain 8-9 % less weight than control mice.

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