(S)-(-)-Bay-K-8644,98625-26-4

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(S)-(-)-Bay-K-8644

CAS No. : 98625-26-4

MCE 国际站：(S)-(-)-Bay-K-8644

产品活性：(S)-(-)-Bay-K-8644 是 L 型钙离子通道激动剂。(S)-(-)-Bay-K-8644 激活 Ba²⁺电流 (I_Ba)，EC₅₀ 为 32 nM。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：Calcium Channel

In Vitro: (±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca²⁺ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and (S)-(-)-Bay-K-8644 as an agonist. (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on I_Ba in gastric myocytes of the guinea pig antrum. The Ca²⁺ channel activity is enhanced by 3–30 μM (S)-(-)-Bay-K-8644 an agonist of L-type Ca²⁺ channels. The interactions of two Ca²⁺ channel activators (S)-(-)-Bay-K-8644 and FPL 64176 is examined on smooth muscle L-type Ca²⁺ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC₅₀=14 nM). (S)-(-)-Bay-K-8644 (100 nM) increases whole-cell Ca²⁺ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176.

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