Fibronectin抗体

Fibronectin抗体产品信息

免疫原 :
Recombinant human Fibronectin Fragment 2 protein ( Catalog#10314-H08H )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human Fibronectin Fragment 2 ( Catalog#10314-H08H; Ser 607- Pro 1265; CAD91166 ). Total IgG was purified by Protein A affinity chromatography.
Fibronectin抗体 Background
Fibronectin (FN) is a large glycoprotein present as soluble disulfide-linked dimeric form in plasma and body fluids, and as dimeric or multimeric form at the cell surface or in extracellular matrix (ECM). Each monomer of FN consists of three types of homologous repeating units, that is 12 type I repeats, two type II repeats and 15-17 type III repeats. The occurrence of multiple isoforms results from alternative mRNA splicing of the ED-A, ED-B and III-CS regions, and subsequent post-translational modification. As an ECM component and one of the primary cell adhesion molecules, Fibronectin can be a ligand for fibrin, heparin, chondroitin sulfate, collagen/gelatin, as well as many integrin receptors through which FN mediates the variety of cellular signaling pathways. Accordingly, Fibronectin is involved in cell adhesion and migration, growth and differentiation, morphogenesis, wound healing, blood coagulation, host defense, and metastasis. Conversion of the non-functional soluble fibronectin to fibronectin fibrils requires conformational changes and exposure of cryptic epitopes necessary for polymerization. The fragment 2 of FN comprises the first 7 FN type III repeats and is suggested to be important for self association.
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