免疫原 :
Recombinant human CXCL4 protein ( Catalog#10874-HNAE )
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, E.coli-derived, recombinant human CXCL4 ( rh CXCL4 ; Catalog#10874-HNAE ; NP_002610.1 ; Glu 32 - Ser 101 ). Total IgG was purified by Protein A affinity chromatography.
CXCL4 / PF4抗体 Background
Platelet factor 4 (PF4) is a 70-amino acid protein belonging to the CXC chemokine family also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . It is released from the alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. PF4 is chemotactic for neutrophils, fibroblasts and monocytes, and interacts with a splice variant of the chemokine receptor CXCR3, known as CXCR3B. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 plays a critical role in inflammation and wound repair. PF4 is the antigen in heparin-induced thrombocytopenia, an idiosyncratic autoimmune reaction to the administration of the anticoagulant heparin. Its autoantibodies have been found in patients with thrombosis and features resembling HIT but no prior administration of heparin.
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