IL18BP / IL18BPa 抗体

IL18BP / IL18BPa 抗体产品信息

免疫原 :
Recombinant human IL18BP protein ( Catalog#10357-H08H )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human IL18BP N-terminal domain ( rhIL18BP ; Catalog#10357-H08H; NP_001034748.1; Met 1- Gly 192 ). IL18BP specific IgG was purified by human IL18BP affinity chromatography.
IL18BP / IL18BPa 抗体背景综述
Interleukin 18 binding protein (IL18BP) is a secreted glycoprotein which antagonizes the activity of the proinflammatory cytokine IL18 by binding to IL18 and blocking its biological activity. At least four isoforms differing in affinity for IL18 are produced from alternative splicing, and IL18 BP isoform a contains one immunoglobulin (Ig)-like C2-type domain. IL18BPa binds IL18 with high affinity, prevents the binding of IL18 to its receptor, and inhibits the production of IFN- gamma, IL8, and activationof NF-kappa B, resulting in reduced T- helper type 1 (Th1) immune responses. IL18BPa is constitutively expressed and secreted in mononuclear cells, and its expression can be induced and enhanced through the IFN- gamma-mediated pathway.The identified IFN-γ/IL18BPa negative feedback loop probably plays a key role in the modulation of both innate and adaptive immunity. A severe IL18/IL18BP imbalance is associated with hemophagocytic syndrome (HPS) characterized by an uncontrolled activation of Th1 lymphocytes and macrophages. In addition, IL18 BPa is suggested to has a possible antimetastatic benefit, since IL18 plays a significant role in tumor hepatic metastasis.
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