Cystatin-C / Cystatin-3 / CST3

Cystatin-C / Cystatin-3 / CST3抗体产品信息

免疫原 :
Recombinant mouse CST3 protein ( Catalog#50239-M08H )
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant mouse CST3 ( rM CST3 ; Catalog#50239-M08H ; NP_034106.2 ; Met 1 - Ala 140 ). CST3 specific IgG was purified by mouse CST3 affinity chromatography.
Cystatin-C / Cystatin-3 / CST3抗体背景综述
Mouse Cystatin-C, also known as Cystatin-3, Neuroendocrine basic polypeptide, Post-gamma-globulin, and CST3, is a secreted type 2 cysteine proteinase inhibitors of the cystatin superfamily, and exerts actions on a variety of cysteine proteases including papain and Cathepsins B, H, K, L and S. As the most abundant extracellular inhibitor of cysteine proteases, Cystatin-C encoded by a housekeeping gene is found ubiquitously in all organs and biological fluids at high concentration levels. It has been shown that Cystatin-C binds amyloid-beta and reduces cerebral amyloid-beta deposition or inhibits its fibril formation in an APP-transgenic mouse model. Thus, a point mutation in this gene (Leu 68 to Gln) hsa been associated with a severe hereditary form of amyloid angiopathy. Studies have also investigated Cystatin-C as a marker of kidney function and thyroid dysfunction prior to creatinine, and could be a useful clinical tool to identify HIV-infected persons. In addition, Cystatin-C expression is up-regulated in malignance of certain tumor progression.
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