NME1 / NDPKA抗体

NME1 / NDPKA抗体产品信息

免疫原 :
Recombinant human NME1 protein ( Catalog #11615-H07E )
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human NME1 ( rh NME1 ; Catalog #11615-H07E ; NP_000260.1 ; Ala 2 - Glu 152 ). NME1 IgG was purified by human NME1 affinity chromatography.
NME1 / NDPKA抗体背景综述
Nucleoside diphosphate kinase A, also known as NDP kinase A, Tumor metastatic process-associated protein, Metastasis inhibition factor nm23, Granzyme A-activated Dnase, GAAD, NME1 and NDPKA, is a cytoplasm protein which belongs to the NDK family. Isoform 1 of NME1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 NME1 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 NME1 is ubiquitously expressed. NME1 / NDPKA is found in reduced amount in some tumor cells of high metastatic potential. However, increased NME1 levels correlate with aggressive tumor features in neuroblastoma. NME1 / NDPKA may have distinct if not opposite roles in different tumors. NME1 / NDPKA possesses nucleoside-diphosphate kinase, serine / threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. It is involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. NME1 / NDPKA is required for neural development including neural patterning and cell fate determination.
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