CSF2RB / CD131抗体

CSF2RB / CD131抗体产品信息

免疫原 :
Recombinant human CSF2RB protein ( Catalog#10516-H08H )
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human CSF2RB ( rh CSF2RB ; Catalog#10516-H08H ; NP_000386.1 ; Met 1 - Trp 443 ). CSF2RB specific IgG was purified by human CSF2RB affinity chromatography
CSF2RB / CD131抗体背景综述
Colony stimulating factor 2 receptor, beta, low-affinity, also known as Cytokine receptor common subunit beta, CSF2RB, CDw131, and CD131, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 4 subfamily. It is a 897 amino acid protein which the sequence is further processed into a mature form. The cytokine receptor is a heterodimer of an alpha and a beta subunit, and this beta subunit (CD131) is also the common and high affinity receptor to the interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. It contains two fibronectin type-III domains. The WSXWS motif of CD131 appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif of CD131 is required for JAK interaction and/or activation.
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