免疫原 :
Recombinant Mouse SerpinA6 protein (Catalog#50314-M08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Mouse SerpinA6 (rM SerpinA6; Catalog#50314-M08H; Q06770; Met 1-Ala 397). SerpinA6 specific IgG was purified by Mouse SerpinA6 affinity chromatography.
SerpinA6 AntibodyBackground
The serpin peptidase inhibitor, clade A, member 6 (SerpinA6), also known as corticosteroid-binding globulin or CBG, is a member of Serpin (Serine Protease Inhibitors) superfamily. The superfamily of serine protease inhibitors (SERPINs) plays a key role in controlling the activity of proteinases in diverse biological processes. SerpinA6 is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and SerpinA6, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to SerpinA6 in human plasma). In this context, SerpinA6 directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. As a specific high-affinity plasma transport glycoprotein for cortisol. Stress-induced falls in CBG levels may heighten hypothalamic-pituitary-adrenal axis responses and CBG. The tissue interactions may allow targeted cortisol delivery. Three genetic variants of CBG have been identified that reduce cortisol binding affinity and/or CBG levels. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. SerpinA6/CBG is the major transport protein for glucocorticoids and progestins in the blood of most vertebrates, and may involved in obesity and stress sensitivity.
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