IL-17R / IL-17RA抗体

IL-17R / IL-17RA抗体产品信息

免疫原 :
Recombinant Mouse IL-17R / IL-17RA protein (Catalog#50328-M08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Mouse IL-17R / IL-17RA (rM IL-17R / IL-17RA; Catalog#50328-M08H; NP_032385.1; Met 1-Trp 322). IL-17R / IL-17RA specific IgG was purified by Mouse IL-17R / IL-17RA affinity chromatography.
IL-17R / IL-17RA抗体Background
Interleukin-17 receptor A, also known as IL-17 receptor A, IL-17RA, IL17RA and IL17R, is an ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A (IL17A). IL17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL17A binds to a type I cell surface receptor called IL17 Rof which there are at least three variants IL17RA, IL17RB, and IL17RC. IL17RA is a widely expressed glycoprotein that plays a central role in inflammatory responses. IL17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The aa sequence of mouse IL17RA is 69% identical to the human IL17R. Within the extracellular domain, mouse IL17RA shares 72% aa sequence identity with human IL17RA. IL17RA associates with IL17RC to form a signaling receptor complex for IL17 and IL17F. Ligand and IL17RA ligation promotes T cell activation and the production of IL-6, G-CSF, SCF, and multiple proinflammatory chemokines.
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