1) Cat. No.: TRC-M425035; 2) Chemical Name: MK-2461; 3) CAS No.: 917879-39-1; 4) Mol. Formula: C24H25N5O5S; 5) Mol. Weight: 495.55; 6) Packing Size: 100mg / 250mg; 7) Appearence: ; 8) Application Notes: MK-2461 is a novel ATP-competitive multitargeted kinase inhibitor that preferentially inhibits the activated c-Met receptor. MK-2461 is also a potent inhibitor of Ron, Flt1, Flt 3, PDGFRβ, and Mer receptors. Recent studies show that MK-2461 siginifciantly suppresses tumor growth of GTL-16 xenografts in mice and MK-2461 treatments effectively inhibit the growth of NIH3T3 tumors harboring c-Met single nucleotide mutants T3936C and T3997C.; 9) Synonym: N-((2R)-1,4-Dioxan-2-ylmethyl)-N-methyl-N'-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfamide ; 10) Solubility: ; 11) Storage condition: ; 12) References: Pan, B.S. et al.: Cancer Res., 70, 1524 (2010); Park, Y.W. et al.: Anal. Biochem., 269, 94 (1999);