SECTM1抗体

SECTM1抗体产品信息

免疫原 :
Recombinant Human SECTM1 protein (Catalog#12269-H08H)
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
5F2D2
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SECTM1 (rh SECTM1; Catalog#12269-H08H; Q8WVN6-1; Met 1-Gly 145). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
SECTM1抗体 Background
Secreted and transmembrane 1 (SECTM1) protein, or K12 protein is a member of the SECTM family. This transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. SECTM1/K12 was originally identified by its location just upstream of the CD7 locus. The human K12 protein has been shown to be primarily expressed in spleen, prostate, testis, small intestine, and in peripheral blood leukocytes. Immunohistochemical analysis of peripheral blood cells shows that K12 is found in leukocytes of the myeloid lineage, with the strongest staining observed in granulocytes and no detectable expression in lymphocytes. Thus, it concludes that K12 is a novel molecule with potential importance in hematopoietic and/or immune system processes. K12/SECTM1may be involved in thymocyte signaling, and plays in T cell activation. In addition, the thymic microenvironment-produced K12 in regulation of thymocyte signaling and cytokine release, particularly in the setting of thymus pathology where IFN-gamma is upregulated such as myasthenia gravis.
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