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- hz-11229-R106
- 2025年07月12日
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- 文献和实验
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
H9N2 Hemagglutinin / HA抗体
免疫原 :
Recombinant H9N2 HA protein ( Catalog#11229-V08H )
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
106
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Influenza A virus H9N2 Hemagglutinin.
H9N2 Hemagglutinin / HA抗体背景综述
Influenza (flu) is a respiratory infection in mammals and birds. This virus is divided into three main types (A, B and C). Influenza A is found in a wide variety of bird and mammal species. Influenza B is largely confined to humans and is an important cause of morbidity. Influenza C infects humans, dogs and pigs, sometimes causing both severe illness and local epidemics. Influenza A is further divided into subtypes based on differences in the membrane proteins hemagglutinin (HA) and neuraminidase (NA). The notation HhNn is used to refer to the subtype comprising the hth discovered HA protein and the nth discovered NA protein. The HA is a trimer with a receptor binding pocket on the globular head of each monomer. Subtypes are further divided into strains. Each genetically distinct virus isolate is usually considered to be a separate strain.
H9N2 is a subtype of Influenza A. Hemagglutinin (HA) is a Single-pass type I integral membrane glycoprotein from the influenza virus, and comprises over 80% of the envelope proteins present in the virus particle. It is a homotrimer of disulfide-linked HA1-HA2. Binding of HA to sialic acid-containing receptors on the surface of its target cell brings about the attachment of the virus particle to the cell and forms a endosome. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the hydrophobic portion “fusion peptide”. After which, virus penetrates the cell and pours its contents including the RNA genome into the cytoplasm mediated by fusion of the endocytosed virus particle’s own membrane and the endosomal membrane. Hemagglutinin plays a major role in the determination of host range restriction and virulence.
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文献和实验)、半乳糖、甘露糖、墨角藻糖和氨基葡糖，在病毒粒子中主要以糖蛋白或糖脂的形式存在。 病毒蛋白及潜在的糖基化位点是病毒基因组特异的，但病毒膜的糖蛋白或糖类链的脂质和碳水化合物链的成分，是由宿主细胞确定的。 抗原解释 流感病毒的抗原结构分为H和N两大类。H代表Hemagglutinin(血细胞凝集素)，有如病毒的钥匙，用来打开及入侵人类或牲畜的细胞；N代表神经氨酸酶(Neuramidinase)，是帮助病毒感染其他细菌的酵素。 病毒抵抗力 禽流感
酶解再向β折叠链的构象转变成无活力的裂解型(cleaved-form, C型)［11］. L型抑制剂可以通过变性和复性方法转变成A型, 然后又慢慢变成L型. 流感病毒血细胞凝集素(influenza hemagglutinin, HA)在pH诱导下的结构变化与细胞膜融合功能紧密相关的. HA在pH 7.0时, 其空间结构是由helix-loop-helix的头状单体结构域组成的三聚体蛋白(HA-N); 可在低pH(pH＜5)条件下, 中间Loop区域转化为螺旋结构并与另两段螺旋连接共同形成一股长螺旋
Two-hybrid analysis of genetic
).The most commonly used prey plasmid,pJG4-5,expresses proteins fused to the B42 activation domain,the SV40 nuclear localization signal,and an epitope tag derived from hemagglutinin,all driven by the yeast GAL1 promoter which is active only in yeast grown on galactose
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