TGF-beta1抗体

TGF-beta1抗体产品信息

免疫原 :
Recombinant Human TGF-beta1 protein (Catalog#10804-HNAH)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
016
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Human TGF-beta 1 (rh TGF-beta 1; Catalog#10804-HNAH; NP_000651.3; Ala 279-Ser 390).
TGF-beta1抗体Background
Transforming growth factor beta 1 (TGFβ1)is a member of thelarge transforming growth factor beta superfamilyofcytokines, and serves as a multifunctional molecule performing actions in many cellular functions, including the control ofcell growth,cell proliferation,cell differentiation and apoptosis. TGFβ1 was first synthesized as a 390 amino acid precusor. The secreted proprotein contains 360 aa, and is cleaved into mature TGFβ1 (112 aa) and latency-associated peptide (LAP) (248 aa), which remains non-covalently linked to mature TGFβ1 rendering it inactive. TGFβ1 is synthesized by many cells, and regulates many other growth factors both in positive and negative manner. It has been shown that TGFβ1 plays an important role in controlling the immune system and shows different activities on different types of cell, or cells at different developmental stages. It is highly expressed in bone and as a potent stimulator of osteoblastic bone formation. TGFβ1 is able to cause chemotaxis, proliferation and differentiation in committed osteoblasts. TGFβ1 is also identified as a disease marker and a therapeutical target for cardiovascular disease.
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