ARG1 / Arginase 1抗体

ARG1 / Arginase 1抗体产品信息

免疫原 :
Recombinant Human ARG1 / Arginase 1 protein (Catalog#11558-H08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
034
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Human ARG1 / Arginase 1 (rh ARG1 / Arginase 1; Catalog#11558-H08H; P05089-1; Met 1-Lys 322).
ARG1 / Arginase 1抗体Background
Arginase-1, also known as Liver-type arginase, Type I arginase and ARG1 is a cytoplasm protein which belongs to thearginase family. Arginase-1 / ARG1 is a manganese-containing enzyme. The reaction catalyzed by this enzyme is: arginine + H2O → ornithine + urea. It is the final enzyme of the urea cycle. Arginase-1 / ARG1 is the fifth and final step in the urea cycle, a series of biophysical reactions in mammals during which the body disposes of harmful ammonia. Specifically, Arginase-1 / ARG1 converts L-arginine into L-ornithine and urea. In most mammals, two isozymes of this enzyme exist; the first, Arginase-1 / ARG1, functions in the urea cycle, and is located primarily in the cytoplasm of the liver. The second isozyme, Arginase-2 / ARG2, has been implicated in the regulation of the arginine/ornithine concentrations in the cell. It is located in mitochondria of several tissues in the body, with most abundance in the kidney and prostate. Defects in Arginase-1 / ARG1 are the cause of argininemia (ARGIN), also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs.
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