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- xy11064-RP01
- 2025年07月15日
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- 详细信息
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
IL32 alpha抗体
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human IL32 isoform alpha (rhIL32 alpha; Catalog#11064-H08H; NP_001012651.1; Met 1-Lys 131). Total IgG was purified by Protein A affinity chromatography.
IL32 alpha抗体 Background
IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines ( TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. Upon stimulation with inflammatory cytokines, IL-32 is abundantly expressed in epithelial and endothelial cells. It is regulated robustly by other major proinflammatory cytokines, and is crucial to inflammation and immune responses. IL-32 has been involved in Mycobacterium tuberculosis and chronic proinflammatory diseases such as rheumatoid arthritis. It is a potent inducer of prostaglandin E release in mouse macrophages and human blood monocytes, an important property for inflammation. Four of the IL-32 isoforms (alpha, beta, gamma and delta) are the most representative IL-32 transcripts, and gamma isoform of IL-32 is the most active, although all isoforms are biologically active.
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