CD32b / FCGR2B抗体

Receptors that recognize the Fc portion of IgG (Fcγ Rs) functions in the regulation of immune response and are divided into three classes designated Fcγ RI (CD64), Fcγ RII (CD32), and Fcγ RIII (CD16). Fcγ RI binds IgG with high affinity and functions during early immune responses, whereas Fcγ RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Three closely related genes encodes human CD32 class by and designated Fcγ RII A, B, and C which share 94 - 99% amino acid identity in their extracellular domains. Fcγ RII B (CD32b) is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. As the only inhibitory member in human, Fcγ RII B has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and delivers an inhibitory signal upon ligand binding. The coordinated functioning of activating and inhibitory receptors is necessary for successful and proper initiation, amplification, and termination of immune responses, and accordingly, the Fcγ RII B plays an important negative-regulating role through modulating the signals from activation receptors. Recent study has identified CD32b expression in a variety of B-cell malignancies, suggesting that it is a potential immunotherapeutic target for B-cell lymphoproliferative disorders.
CD32b / FCGR2B抗体相关产品如下：xyR-0362xy Protein A/RBITC罗丹明标记蛋白A
xyR-0326xy Bovine IgG/RBITC罗丹明标记牛IgG
xyR-0327xy Bovine IgM/RBITC罗丹明标记牛IgM
xyR-0310xy Chicken IgG/RBITC罗丹明标记鸡IgG
xyR-0314xy Chicken IgM/RBITC罗丹明标记鸡IgM
xyR-0303xy dog IgG/RBITC罗丹明标记狗IgG
xyR-0370xy Goat IgM/RBITC罗丹明标记羊IgM
xyR-0358xy Guinea IgG/RBITC罗丹明标记豚鼠IgG
xyR-0375xy Guinea IgM/RBITC罗丹明标记豚鼠IgM
xyR-0308xy Horse IgG/RBITC罗丹明标记马IgG
xyR-0374xy Horse IgM/RBITC罗丹明标记马IgM
xyR-0297xy human IgG/RBITC罗丹明标记人IgG
xyR-0345xy human IgM/RBITC罗丹明标记人IgM
xyR-0360xy human IgA/RBITC罗丹明标记人IgA
xyR-0335xy Monkey IgG/RBITC罗丹明标记猴IgG
xyR-0336xy Monkey IgM/RBITC罗丹明标记猴IgM
xyR-0368xy Mouse IgM/RBITC罗丹明标记小鼠IgM
xyR-0309xy pig IgG/RBITC罗丹明标记猪IgG
xyR-0777xy Mink IgG/RBITC罗丹明标记水貂IgG
xyR-0369xy Rabbit IgM/RBITC罗丹明标记兔IgM
xyR-0346xy Rat IgM/RBITC罗丹明标记大鼠IgM
xyR-0884xy rHIL-1Ra/RBITC罗丹明标记重组人白介素-1受体拮抗剂
xyR-0789xy Insulin Protein/RBITC罗丹明标记猪胰岛素蛋白
xyR-xy0002 KLH/RBITC罗丹明标记血蓝蛋白
xy-0283xy-RBITxy OVA/RBITC罗丹明标记鸡卵白蛋白
xyR-2179xy AACT/RBITC罗丹明标记胰糜蛋白酶
xyF-0789xyH Insulin Protein/FITC荧光素标记人胰岛素蛋白
xyGA-0360G Goat Anti-human IgA/Gold金标记羊抗人IgA(10nm/15nm)
xyGA-0360R Rabbit Anti-human IgA/Gold金标记兔抗人IgA(10nm/15nm)
xyGA-0356R Rabbit Anti-digoxin/Gold金标记兔抗 (10nm/15nm)
xyGA-0312xy Avidin/Gold金标记亲合素(10nm/15nm)
xyGA-0362xy Protein A/Gold金标记蛋白A(10nm/15nm)
xy-0360G Goat Anti-human IgA羊抗人免疫球蛋白A
xyA-8 Rabbit Anti-human k-chain兔抗人k-链（亲和层析纯化）