IL17Rd / SEF抗体

IL17Rd / SEF抗体产品信息免疫原 : Recombinant human IL17Rd protein ( Catalog#10507-H08H )

抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human IL17Rd ( rhIL17Rd; Catalog#10507-H08H; NP_060033.3; Met 1- Arg 299 ). IL17Rd specific IgG was purified by human IL17Rd affinity chromatography.
IL17Rd / SEF抗体 Background
Human SEF (similar expression to fgf genes), also known as interleukin 17 receptor D (IL17 Rd), is a type I transmembrane receptor that shares sequence homology with the intracellular domain of members of the IL-17 receptor family. It is highly expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon and heart. Two transcript variants resulting from alternative splicing exit, and the full-length long form is found in both the cytoplasm and plasma membrane. SEF is highly conserved in zebrafish, mouse, and humans, and studies in each system indicate that SEF acts as a feedback inhibitor of FGF-mediated Ras-MAPK signaling and ERK activation by inhibiting FGFR1 tyrosine phosphorylation and/or Ras downstream events. Additionally, SEF is also identified as a mediator of JNK and apoptosis by activating JNK through a TAK1-MKK4-JNK pathway. Human SEF is likely to play critical roles in endothelial or epithelial functions such as proliferation, migration, and angiogenesis.
IL17Rd / SEF抗体相关产品如下：xy-3675R R-cadherinR-钙粘附分子抗体
xy-6168R RAB8Bras癌基因家族RAB8B抗体
xy-6169R RALBRas样蛋白B抗体
xy-6123R Rb2 p130视网膜母细胞瘤相关蛋白p130抗体
xy-7709R Retinoic acid induced 17维甲酸诱导蛋白17抗体
xy-6902R RanGAP1RAN GTPase酶激活蛋白1抗体
xy-7723R REC8减数分裂重组蛋白家族REC8抗体
xy-3676R RALDH2视黄醛脱氢酶2型抗体
xy-3691R REG4再生基因蛋白4抗体
xy-11619R RTP3受体转运蛋白3抗体
xy-11620R RGS21G蛋白信号调节蛋白21抗体
xy-10036R REG4再生基因蛋白4抗体
xy-10055R RIP1受体相互作用蛋白激酶1抗体
xy-8165R RB1CC1RB1的诱导卷曲蛋白RB1CC1抗体
xy-8495R RNF211环指蛋白211抗体
xy-8497R RENBP肾素结合蛋白抗体
xy-8493R RFPL2+RFPL3RET指蛋白样2/3抗体
xy-8496R RFESDRFESD蛋白抗体
xy-8498R REG1 beta胰岛细胞再生因子β抗体
xy-8376R RNF160环指蛋白160抗体
xy-8333R RDH13视黄醇脱氢酶13抗体
xy-8391R RNF75环指蛋白75抗体
xy-8392R RIT1RIT1蛋白抗体
xy-9246R RNF19B环指蛋白19B抗体
xy-8509R Reg3a胰岛β细胞生长因子抗体
xy-9228R RNF149环指蛋白149抗体
xy-9230R RNF158心脏蛋白磷酸酶1结合蛋白/环指蛋白158抗体
xy-9233R RNF180环指蛋白180抗体
xy-9249R RNF123环指蛋白123抗体
xy-8499R RED软骨肉瘤相关蛋白2抗体
xy-8494R RNF210环指蛋白210抗体
xy-9238R RNF23环指蛋白23抗体
xy-9239R RNF24环指蛋白24抗体
xy-9240R RNF25环指蛋白25抗体
xy-9241R RNF31环指蛋白31抗体