Leptin / LEP抗体

Leptin / LEP抗体产品信息免疫原 : Recombinant human Leptin protein ( Catalog#10221-HNAE )

抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human Leptin ( rh Leptin ; Catalog#10221-HNAE ; NP_000221.1 ; Val 22 - Cys 167 ). Leptin specific IgG was purified by human Leptin affinity chromatography.
Leptin / LEP抗体背景综述
Human Leptin is one of the most important adipose-derived hormones, and plays a key role in body weight regulation by governing food intake and energy homeostasis. Leptin is produced and secreted mainly by adipocytes, stomach and placenta, and its concentration is affected by several physiological factors such as age, sex, puberty onset and food intake. Leptin exerts actions through its receptor LepRb present in a number of hypothalamic nuclei, partly involved in the satiety signal pathway, and thus inhibit food intake and/or regulate energy expenditure. In addition, leptin is also identified as a new metabolic and neuroendocrine mediator, and functions in a variety of biological processes including glucose metabolism, immune and inflammatory responses, bone mass regulation, as well as normal sexual maturation and reproduction. Leptin deficiency is implicated in severe obesity, morbid obesity with hypogonadism and impaired cell-mediated immunity.
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