​ALK-3 / BMPR-1A / CD292抗体

ALK-3 / BMPR-1A / CD292抗体产品信息免疫原 : Recombinant mouse ALK-3 protein ( Catalog#50078-M08H )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant mouse ALK-3 ( rM ALK-3 ; Catalog#50078-M08H ; NP_033888.2 ; Met 1 - Arg 152 ). Total IgG was purified by Protein A affinity chromatography
ALK-3 / BMPR-1A / CD292抗体背景综述
The bone morphogenetic protein (BMP) receptors (BMPRs) are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR-IA and BMPR-IB and the type I I receptor BMPR2. These receptors are closely related to the activin receptors, ACVR1 and ACVR2. BMPR-IA and BMPR-IB regulate distinct processes during limb development. Mouse ALK3, also known as BMPR-IA, is specifically expressed in prehypertrophic chondrocytes. It regulates chondrocyte differentiation, serving as a downstream mediator of Indian Hedgehog (IHH) function in both a local signaling loop and a longer-range relay system to PTHrP. BMPR-IA is also responsible for juvenile polyposis syndrome and Cowden's disease.The ligands of BMPRs are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with the 2 different types of serine (threonine) kinase receptors
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