TNFRSF19 / TROY抗体

TNFRSF19 / TROY抗体产品信息免疫原 : Recombinant mouse TNFRSF19 protein ( Catalog#50148-M08H )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant mouse TNFRSF19 ( rM TNFRSF19 ; Catalog#50148-M08H ; NP_001157627.1 ; Met 1 - Leu 170 ). Total IgG was purified by Protein A affinity chromatography
TNFRSF19 / TROY抗体背景综述
Mouse tumor necrosis factor receptor superfamily member 19, also known as, Toxicity and JNK inducer, TNFRSF19, TRADE and Troy, is a member of the TNF-receptor superfamily and contains 3 TNFR-Cys repeats. TNFRSF19 is highly expressed in adult brain, and in embryos from day 11-17, but not earlier. It is detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, TNFRSF19 is mainly expressed in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. TNFRSF19 has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. TNFRSF19 is the first TNFRSF member that is identified as a biomarker for melanoma. TNFRSF19 also presents a potentially novel cell surface signaling target for inhibitors, cell and/or antibody-based immunotherapies.
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