CNTFR / CNTFR-alpha抗体

CNTFR / CNTFR-alpha抗体产品信息免疫原 : Recombinant human CNTFR protein ( Catalog#11012-H08B )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human CNTFR ( rh CNTFR ; Catalog#11012-H08B ; NP_001833.1 ; Met 1 - Pro 346 ). Total IgG was purified by Protein A affinity chromatography
CNTFR / CNTFR-alpha抗体背景综述
Human Ciliary neurotrophic factor receptor subunit alpha, also known as CNTF receptor subunit alpha, CNTFR-alpha, and CNTFR is a cell membrane protein which belongs to the type I cytokine receptor family and Type 3 subfamily. CNTFR contains two fibronectin type-III domains and one Ig-like C2-type (immunoglobulin-like) domain. Ciliary neurotrophic factor (CNTF) is expressed in glial cells within the central and peripheral nervous systems. CNTF stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types such as sensory, sympathetic, ciliary and motor neurons. CNTF is not essential for neural development, but instead acts in response to injury or other stresses. The CNTF receptor complex is most closely related to, and shares subunits with the receptor complexes for interleukin-6 and leukemia inhibitory factor. The specificity conferring alpha subunit of the CNTF complex (CNTFR alpha), is extremely well conserved across species, and has a distribution localized predominantly to the nervous system and skeletal muscle. CNTFR alpha lacks a conventional transmembrane domain and is thought to be anchored to the cell membrane by a glycosyl-phosphatidylinositol linkage.
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