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Mouse C-reactive Protein / CRP抗体
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant mouse CRP ( rM CRP ; Catalog#50409-M08H ; NP_031794.3 ; Met 1 - Ser 225 ). Total IgG was purified by Protein A affinity chromatography
Mouse C-reactive Protein / CRP抗体背景综述
Mouse C-reactive protein (CRP) is a protein found in the blood, the levels of which rise in response to inflammation (an acute-phase protein). CRP is synthesized by the liver in response to factors released by fat cells (adipocytes). It is a member of the pentraxin family of proteins. The physiological role of CRP is to bind to phosphocholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system via the C1Q complex. CRP is a member of the class of acute-phase reactants, as its levels rise dramatically during inflammatory processes occurring in the body. This increment is due to a rise in the plasma concentration of IL-6, which is produced predominantly by macrophages as well as adipocytes. CRP binds to phosphocholine on microbes. It is thought to assist in complement binding to foreign and damaged cells and enhances phagocytosis by macrophages which express a receptor for CRP. It is also believed to play another important role in innate immunity, as an early defense system against infections. CRP rises up to 50,000 fold in acute inflammation, such as infection. It rises above normal limits within 6 hours, and peaks at 48 hours. Its half-life is constant, and therefore its level is mainly determined by the rate of production. Patients with elevated basal levels of CRP are at an increased risk of diabetes, hypertension and cardiovascular disease.
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xy-0535xy TFF3 (trefoil factor3)三叶肽因子3(多肽)
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xy-1300xy Tie2(Porcine tyrosine kinase with immunoglobulin-like and EGF-like domains 2)上皮生长因子样域酪氨酸激酶2抗原
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xy-1444xy TLR3 (Toll-like receptor 3)Toll样受体3抗原
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xy-1197xy TLR5/CD285 (Toll-like receptor 5)Toll样受体5抗原
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xy-0093xy TNF- Beta(Tumor Necrosis Factor- Beta)肿瘤坏死因子-β抗原
xy-2104xy TNFAIP1(Tumor necrosis factor-alpha-induced protein 1)肿瘤坏死因子α诱导蛋白1抗原
xy-1203xy TOPO II Alpha/DNA TP II Alpha (DNA topoisomerase II Alpha)DNA拓普西异构酶Ⅱ抗原
xy-0329xy TRA16 (Testicular orphan nuclear receptor-4 (TR4)-associated protein)睾丸激素受体相关蛋白/孤儿素受体相关蛋白(抗原)
xy-1202xy TRADD(TNF receptor 1 associated via death domain)有死亡区的肿瘤坏死因子受体1相关蛋白抗原
xy-1212xy TRAF1肿瘤坏死因子受体相关因子1抗原
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文献和实验Combined 3C-ChIP-Cloning (6C) Assay: A Tool to Unravel Protein-Mediated Genome Architecture
between chromatin elements without specifically identifying the protein components that mediate such interactions. Here we describe a detailed protocol for C ombined 3C -C hIP-C loning (6C) technology, which combines multiple techniques to identify the proteins
Translocation Assays of Protein Kinase C Activation
The protein kinase C (PKC) family members include at least 11 different isoforms that, based on their different requirements for activation, have been divided into three subfamilies, the Ca2+ -dependent (cPKCα, (βI , βII
Mutational Analysis of the Human Protein C Gene
(2 ,3 ). The gene is approximately 11 kb long and is composed of 9 exons and 8 introns. In common with factors VII, IX and X the exons encode specific structural domains of the protein C molecule. Exon 1 encodes the 5′ untranslated region, exon 2 encodes the signal
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