CD30 / TNFRSF8抗体

CD30 / TNFRSF8抗体产品信息免疫原 : Recombinant Human CD30 / TNFRSF8 protein (Catalog#10777-H08H)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human CD30 / TNFRSF8 (rh CD30 / TNFRSF8; Catalog#10777-H08H; NP_001234.2; Met 1-Lys 379). Total IgG was purified by Protein A affinity chromatography.
CD30 / TNFRSF8抗体 Background
Human CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily and is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. Upon ligand binding, CD30 can initiate the signal transduction that leads to the activation of NF-kappaB mediated by the adaptor proteins TRAF2 and TRAF5. As a regulator of apoptosis, CD30 induces cell death or proliferation, depending on thecell type, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD30 is expressed in embryonal carcinoma but not in seminoma, thus serving as a useful marker in distinguishing these germ cell tumors. Also, CD30 is expressed on classical Hodgkin Lymphoma cells together with CD15.
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