缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human IL-1R9 / IL1RAPL2 (rh IL-1R9 / IL1RAPL2; Catalog#10156-H08H; NP_059112.1; Met 1-Glu 356). IL-1R9 / IL1RAPL2 specific IgG was purified by Human IL-1R9 / IL1RAPL2 affinity chromatography.
IL-1R9 / IL1RAPL2抗体 Background
IL1R9, also known as IL1 receptor accessory protein-like 2 (IL1RAPL2) and three immunoglobulin domain containing IL1 receptor-related molecule 1 (TIGIRR-1), is a member of the interleukin 1 receptor family comprising at least nine members. It is a type I transmembrane glycoprotein with an extracellular region containing three Ig-like domains, a transmembrane domain and a cytoplasmic region containing an intracellular TIR (Toll-like receptor/IL1 receptor signaling) domain that is conserved in most IL1R members and Toll-like receptor family. IL1R9 shows restricted expression in fetal brain and is highly homologous (63%) to IL1RAPL1 expressed in hippocampus. Both IL1RAPL2 and IL1RAPL1 have a C-terminal cytoplasmic extension beyond the TIR domain by comparison to other members, yet neither receptor can directly mediate NF-κB activation in response to IL1 or IL18. IL1R9 gene is co-localized to human chromosome Xq22 with IL1RAPL1 which is reportedly involved in X-linked mental retardation.
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