Neuroligin 1 / NLGN1抗体

Neuroligin 1 / NLGN1抗体产品信息免疫原 : Recombinant Human Neuroligin 1 / NLGN1 protein (Catalog#11617-H08H)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human Neuroligin 1 / NLGN1 (rh Neuroligin 1 / NLGN1; Catalog#11617-H08H; NP_055747.1; Met 1-Ser 677). Neuroligin 1 / NLGN1 specific IgG was purified by Human Neuroligin 1 / NLGN1 affinity chromatography.
Neuroligin 1 / NLGN1抗体 Background
Neuroligin-1, also known as NLGN1, is a single-pass type I membrane protein which belongs to thetype-B carboxylesterase / lipase family. Neuroligins are cell-adhesion molecules located at the postsynaptic side of the synapse. Neuroligins interact with beta-neurexins and this interaction is involved in the formation of functional synapses. Neurexins and neuroligins are cell adhesion molecules present in excitatory and inhibitory synapses, and they are required for correct neuron network function. These proteins are found at the presynaptic and postsynaptic membranes. Neurexins and neurologins have an essential role in synaptic transmission. Altered neuronal connections during the development of the human nervous system could constitute the basis of the etiology of numerous cases of autism spectrum disorders. Neuroligin-1 / NLGN1 is a neuronal cell surface protein which is involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Neuroligin-1 / NLGN1 seems to play role in formation or maintenance of synaptic junctions. It triggers the de novo formation of presynaptic structures and may be involved in specification of excitatory synapses.
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