CD89 / FCAR抗体

CD89 / FCAR抗体产品信息免疫原 : Recombinant human CD89 protein ( Catalog#10414-H08H )

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
6G3G3E7
Ig Type : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human CD89 / FCAR ( rh CD89 ; Catalog#10414-H08H ; NP_001991.1 ; Met 1- Asn 227 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
CD89 / FCAR抗体 Background
FCAR, also called FcαRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, CD89 associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-CD89 Fab fragments triggers an inhibitory response and additionally induces apoptosis. CD89 play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.
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