NBL1 / DAN / DAND1抗体

NBL1 / DAN / DAND1抗体产品信息免疫原 : Recombinant human NBL1 protein ( Catalog#10169-H08H )
抗体类型: Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
7F8A9D4
抗体宿主 : Mouse IgG2b
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human NBL1 / DAN ( rh NBL1 ; Catalog#10169-H08H; NP_005371.1 ; Met 1 - Asp 180 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
NBL1 / DAN / DAND1抗体背景综述
Human differential screening-selected gene aberrative in neuroblastoma (DAN) originally isolated from a normal lung cDNA library, is a the prototypical member of the DAN family of secreted glycoproteins. There are at least five mammalian protein members in the evolutionarily conserved Dan family including DAN, Gremlin/DRM, Cer1 (Cerberus-related), Dante and PRDC (protein related to DAN and cereberus), and share the C-terminal cystine-knot motif. As a secreted glycoprotein, DAN acts as the BMPs (bone morphogenetic protein) antagonist by binding to BMPs and preventing their interactions with signaling receptor complexes, and accordingly regulates the processes of embryonic development and tissue differentiation. It has been reported that DAN also acts as an inhibitor of cell cycle progression and monocyte chemotaxis, and is closely involved in human neuroblastoma differentiation. DAN thus is regarded as a novel candidate of tumour suppressor.
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