INSR / CD220 / Insulin Recepto

INSR / CD220 / Insulin Receptor抗体产品信息免疫原 : Recombinant human INSR protein ( Catalog#11081-H08H )

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 10D3F10C2

抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human INSR / Insulin Receptor extracellular domain ( rh INSR ; Catalog#11081-H08H ; NP_000199.2 ; Met 1 - Lys 956 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
INSR / CD220 / Insulin Receptor抗体背景综述
The insulin receptor (INSR), also known as CD220, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily, and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding to insulin, including IRS1(insulin receptor substrate 1) and phosphatidylinositol 3'-kinase (PI3K). IRS-1 binding and phosphorylation eventually leads to an increase in the high affinity glucose transporter (Glut4) molecules on the outer membrane of insulin-responsive tissues. INSR isoform long and isoform short are expressed in the peripheral nerve, kidney, liver, striated muscle, fibroblasts and skin, and is found as a hybrid receptor with IGF1R which also binds IGF1 in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibrobasts, spleen and placenta. Defects in INSR are the cause of Rabson-Mendenhall syndrome (Mendenhall syndrome), insulin resistance (Ins resistance), leprechaunism ( Donohue syndrome ), and familial hyperinsulinemic hypoglycemia 5 (HHF5). It may also be associated with noninsulin-dependent diabetes mellitus (NIDDM).
INSR / CD220 / Insulin Receptor抗体相关产品如下：xy-1211xy TOP1MT拓普西异构酶Ⅰ抗原
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xy-4507xy PRRSV M protein猪蓝耳病病毒M蛋白
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六、标记蛋白质与多肽

编号 名 称
xy-4560xyB Taurine/BSA牛磺酸偶联牛血清白蛋白（β-氨基乙磺酸）
xy-0292xy-xyy5 BSA/Cy5荧光素Cy5标记牛血清白蛋白
xy-0292xy-xyy5.5 BSA/Cy5.5荧光素Cy5.5标记牛血清白蛋白
xy-0292xy-xyy3 BSA/Cy3荧光素Cy3标记牛血清白蛋白
xyF-0789xy Insulin Protein/FITC荧光素标记猪胰岛素蛋白
xy-0283xy-FITxy OVA/FITC荧光素标记鸡卵白蛋白
xy-0295xy-FITxy Rabbit IgG/FITC荧光素FITC标记兔IgG(细胞流式同型对照)
xyF-0326xy Bovine IgG/FITC荧光素标记牛IgG
xyf-0327xy Bovine IgM/FITC荧光素标记牛IgM
xyF-0310xy Chicken IgG/FITC荧光素标记鸡IgG
xyf-0314xy Chicken IgM/FITC荧光素标记鸡IgM
xyf-0303xy dog IgG/FITC荧光素标记狗IgG
xyf-0373xy dog IgM/FITC荧光素标记狗IgM
xy-0294xy-FITxy Goat IgG/FITC荧光素FITC标记羊IgG(细胞流式同型对照)
xyf-0370xy Goat IgM/FITC荧光素标记羊IgM
xyf-0358xy Guinea IgG/FITC荧光素标记豚鼠IgG
xyf-0375xy Guinea IgM/FITC荧光素标记豚鼠IgM
xyf-0308xy Horse IgG/FITC荧光素标记马IgG
xyf-0374xy Horse IgM/FITC荧光素标记马IgM
xyF-0297xy human IgG/FITC荧光素标记人IgG
xyf-0345xy human IgM/FITC荧光素标记人IgM
xyf-0360xy human IgA/FITC荧光素标记人IgA
xyF-0335xy Monkey IgG/FITC荧光素标记猴IgG
xyf-0336xy Monkey IgM/FITC荧光素标记猴IgM
xy-0296xy-FITxy Mouse IgG/FITC荧光素FITC标记小鼠IgG(细胞流式同型对照)
xyf-0368xy Mouse IgM/FITC荧光素标记小鼠IgM
xyF-0309xy pig IgG/FITC荧光素标记猪IgG
xyf-0777xy Mink IgG/FITC荧光素标记水貂IgG