Carbonic Anhydrase XII / CA12抗

Carbonic Anhydrase XII / CA12抗体产品信息免疫原 : Recombinant Human Carbonic Anhydrase XII / CA12 Protein (Catalog#10617-H08H)

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 2D6E1

抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant Human Carbonic Anhydrase XII / CA12 (rh Carbonic Anhydrase XII / CA12; Catalog#10617-H08H; NP_001209.1; Met 1-Gln 291 B). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Carbonic Anhydrase XII / CA12抗体 Background
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA12, also known as Car12 and carbonic anhydrase XII, is a type I membrane enzyme highly expressed in colon, kidney, prostate, intestine and activated lymphocytes and moderately expressed in pancreas, ovary, and testis. This bitopic membrane protein contains an N-terminal extracellular catalytic domain, a membrane-spanning α-helix, and a small intracellular C-terminal domain. Two alternatively spliced forms exist, which either contains or lacks a 11 amino acid segment just before the transmembrane domain. The structure reveals a prototypical CA fold and two CA XII domains associate to form an isologous dimer. Overexpression of the CA12 is observed in certain human cancers and is used as a tumor marker.
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