B7-H3 / CD276抗体

B7-H3 / CD276抗体产品信息免疫原 : Recombinant Human B7-H3 / CD276 protein (Catalog#11188-H08H)

Reagents : FITC-conjugated mouse monoclonal antibody
Clone ID : 06

抗体宿主 : Mouse IgG2b
Concentration : 10 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human B7-H3 / CD276 (rh B7-H3 / CD276; Catalog#11188-H08H; Q5ZPR3-1; Met 1-Thr 461) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
B7-H3 / CD276抗体 Background
B7-H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T-cell response. B7 family molecules, which are expressed on antigen-presenting cells and display extracellular regions containing immunoglobulin (Ig) variable (V)- and constant (C)-like domains, are known to modulate T cell receptor (TCR)-mediated T cell activation by providing co-signals that are either stimulatory or inhibitory. B7-H3 provides a stimulatory signal to T cells. However, recent studies suggest a negative regulatory role for B7-H3 in T cell responses. B7-H3 inhibited T cell proliferation mediated by antibody to T cell receptor or allogeneic antigen-presenting cells. B7-H3 is a negative regulator that preferentially affects T (H)1 responses. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. Recently, B7-H3 expression has also been found in a variety of different human cancers, including prostate cancer, clear cell renal cell carcinoma (ccRCC), non-small-cell lung cancer (NSCLC), pancreatic cancer, gastric cancer, ovarian cancer, colorectal cancer (CRC) and urothelial cell carcinoma. B7-H3 was expressed in some human cancers and correlated with poor outcome of cancer patients.
B7-H3 / CD276抗体相关产品如下：xy-0666R Fibronectin纤维连接蛋白抗体
xy-1170R FOS BFosB蛋白抗体
xy-1188R FRA2FRA2/FOSL2抗体
xy-0269R FoxP3叉头蛋白P3抗体
xy-0735R FGF8成纤维细胞生长因子8抗体
xy-6848R Fascin肌动蛋白结合蛋白Fascin抗体
xy-7646R FIS1线粒体裂变1蛋白抗体
xy-1275R FoxP1叉头蛋白P1抗体
xym-1265M F1 protein (YERSINIA PESTIS)鼠疫F1蛋白/鼠疫耶尔森氏菌荚膜抗原F1单克隆抗体
xy-1257R FGF5纤维母细胞生长因子5抗体
xy-6876R FMR1脆性X综合征相关蛋白AFF1抗体
xy-11010R FAM84A感觉神经蛋白1抗体
xy-9601R Frataxin线粒体型共济失调蛋白抗体
xy-8514R Fc ε RIαFC段IgE受体α多肽抗体
xy-8654R FAM81AFAM81A蛋白抗体
xy-9657R FAM78BFAM78B蛋白抗体
xy-9656R C9orf599号染色体开放阅读框59抗体
xy-9658R FAM76AFAM76A蛋白抗体
xy-9659R FAM76BFAM76B蛋白抗体
xy-11011R FAM92A1FAM92A1蛋白抗体
xy-11012R FAM98AFAM98A蛋白抗体
xy-8237R FRMD5FRMD5蛋白抗体
xy-8238R FRMD6FRMD6蛋白抗体
xy-8216R FAM161AFAM161A蛋白抗体
xy-8221R FAM153BFAM153B蛋白抗体
xy-8198R FAM46CFAM46C蛋白抗体
xy-8199R TCRP1舌癌化疗耐药相关蛋白1
xy-8205R FAM129BFAM129B蛋白抗体
xy-8206R RMD2微管动力调节蛋白2抗体
xy-8208R FAM50AFAM50A蛋白抗体
xy-8213R FAM113AFAM113A蛋白抗体
xy-8219R FAM150AFAM150A蛋白抗体
xy-8240R FRMD8FRMD8蛋白抗体
xy-8345R FGFR1OPFGFR1癌基因伴侣蛋白抗体