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- Abcam
- 中国/美国/德国
- xy80075-MM10
- 2025年07月08日
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- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
Interleukin-2 / IL-2抗体
Interleukin-2 / IL-2抗体产品信息免疫原 : Recombinant Rat Interleukin-2 / IL-2 protein (Catalog#80075-RNAE)
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 10
抗体宿主 : Mouse IgG2b
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat Interleukin-2 / IL-2 (rR Interleukin-2 / IL-2; Catalog#80075-RNAE; P17108; Ala21-Gln155). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Interleukin-2 / IL-2抗体 Background
Interleukin-2, also known as T-cell growth factor, TCGF, Aldesleukin and IL2, is a secreted protein which belongs to theIL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleukin-2 / IL-2 molecule was first purified to homogeneity by immunoaffinity chromatography by Kendall Smith and his team at Dartmouth Medical School. Interleukin-2 / IL-2 was also the first cytokine shown to mediate its effects via a specific IL-2 receptor, and it was also the first interleukin to be cloned and expressed from a complementary DNA (cDNA) library. Interleukin-2 / IL-2 was designated number 2 because Smith's data at the time indicated that IL-1, produced bymacrophages, facilitates IL-2 production by T lymphocytes (T cells).
Interleukin-2 / IL-2 is produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Interleukin-2 / IL-2 is normally produced by the body during an immune response. When environmental substances (molecules or microbes) gain access to the body, these substances (termed antigens) are recognized as foreign by antigen receptors that are expressed on the surface of lymphocytes. Antigen binding to the T cell receptor (TCR) stimulates the secretion of Interleukin-2 / IL-2, and the expression of IL-2 receptors IL-2R. The IL-2 / IL-2R interaction then stimulates the growth, differentiation and survival of antigen-selected cytotoxic T cells via the activation of the expression of specific genes. Interleukin-2 / IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
The World Reference Standard for Interleukin-2 / IL-2 is produced by the National Institute of Biological Standards and Control in the UK. A recombinant form of Interleukin-2 / IL-2 for clinical use is manufactured by Chiron Corporation with the brand name Proleukin. It has been approved by the Food and Drug Administration (FDA) for the treatment of cancers (malignant melanoma, renal cell cancer), and is in clinical trials for the treatment of chronic viral infections, and as a booster (adjuvant) for vaccines. The use of Interleukin-2 / IL-2 in HIV therapy has been found to be ineffective.
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Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 10
抗体宿主 : Mouse IgG2b
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat Interleukin-2 / IL-2 (rR Interleukin-2 / IL-2; Catalog#80075-RNAE; P17108; Ala21-Gln155). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Interleukin-2 / IL-2抗体 Background
Interleukin-2, also known as T-cell growth factor, TCGF, Aldesleukin and IL2, is a secreted protein which belongs to theIL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleukin-2 / IL-2 molecule was first purified to homogeneity by immunoaffinity chromatography by Kendall Smith and his team at Dartmouth Medical School. Interleukin-2 / IL-2 was also the first cytokine shown to mediate its effects via a specific IL-2 receptor, and it was also the first interleukin to be cloned and expressed from a complementary DNA (cDNA) library. Interleukin-2 / IL-2 was designated number 2 because Smith's data at the time indicated that IL-1, produced bymacrophages, facilitates IL-2 production by T lymphocytes (T cells).
Interleukin-2 / IL-2 is produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Interleukin-2 / IL-2 is normally produced by the body during an immune response. When environmental substances (molecules or microbes) gain access to the body, these substances (termed antigens) are recognized as foreign by antigen receptors that are expressed on the surface of lymphocytes. Antigen binding to the T cell receptor (TCR) stimulates the secretion of Interleukin-2 / IL-2, and the expression of IL-2 receptors IL-2R. The IL-2 / IL-2R interaction then stimulates the growth, differentiation and survival of antigen-selected cytotoxic T cells via the activation of the expression of specific genes. Interleukin-2 / IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
The World Reference Standard for Interleukin-2 / IL-2 is produced by the National Institute of Biological Standards and Control in the UK. A recombinant form of Interleukin-2 / IL-2 for clinical use is manufactured by Chiron Corporation with the brand name Proleukin. It has been approved by the Food and Drug Administration (FDA) for the treatment of cancers (malignant melanoma, renal cell cancer), and is in clinical trials for the treatment of chronic viral infections, and as a booster (adjuvant) for vaccines. The use of Interleukin-2 / IL-2 in HIV therapy has been found to be ineffective.
Interleukin-2 / IL-2抗体相关产品如下：xy-12130R ACCN5小肠钠通道蛋白5抗体
xy-12131R APXLAPXL蛋白抗体
xy-12132R ASIC3酸敏感离子通道蛋白3抗体
xy-12137R Aspartate beta hydroxylase天门冬氨酸β羟化酶抗体
xy-10014R AVPR2精氨酸加压素受体2抗体
xy-7119R ARP3细胞骨架肌动蛋白样蛋白3抗体
xy-6322R Annexin A8膜粘连蛋白8抗体
xy-6786R Aquaporin 8水通道蛋白8抗体
xy-9399R ANKRD40锚蛋白重复结构域蛋白40抗体
xy-1252R API5凋亡抑制因子5抗体
xy-1253R AQP3水通道蛋白-3抗体
xy-1254R APOD载脂蛋白D抗体
xy-7641R ACSM3丁酰基辅酶A合成酶3抗体
xy-7643R ARTS1脂肪细胞源性亮氨酸氨基肽酶抗体（血管内皮细胞生长因子诱导蛋白）
xy-7655R AIFM2线粒体凋亡诱导因子2抗体
xy-1230R ABL2ABL2蛋白抗体
xy-0439R ACE血管紧张素转换酶ACE1抗体
xy-1004R ACE2血管紧张素转换酶2抗体
xy-0120R AcinusAcinus抗体
xy-1227R Ack1醋酸激酶1抗体
xy-0443R ACTH (1-39)促肾上腺皮质激素(1-39)抗体
xy-0442R ACTH (18-39)促肾上腺皮质激素ACTH(18-39)抗体
xy-0004R ACTH (7-23)促肾上腺皮质激素ACTH (7-23)抗体
xy-0039R ADNP活性依赖的神经保护肽抗体
xy-6852R Alpha 1 Acid Glycoproteinα1酸性糖蛋白1/类粘蛋白1抗体
xy-7565R Alpha 1 acid glycoprotein 2α1酸性糖蛋白2抗体（类粘蛋白2）
xy-4610R phospho-AQP2(Ser264+261)磷酸化水通道蛋白2抗体
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xy-1960R ABCF1ATP结合盒蛋白家族GCN20F家族1抗体
xy-2405R AKR1B1醛糖还原酶抗体
xy-0945R Serum albumin人血清白蛋白抗体
xy-0935R Anthrax炭疽菌抗体（采用活疫苗制备）
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文献和实验相关实验
Cytokines As Vaccine Adjuvants: The Use of Interleukin-2
-macrophage colony stimulating factor (GM-CSF), and interleukin-2 (IL-2), (reviewed in 1 and 2 ). The addition of recombinant or nucleic acid-derived cytokine(s) to a vaccine regimen can therefore enhance the endogenous immune response to the vaccine antigen.
脾细胞与小鼠骨髓瘤细胞（P3-X63/Ag8）融合，融合的细胞既获得了亲代脾细胞分泌特异性抗体的特性，又具有骨髓瘤细胞大量繁殖的能力，成为一种既能分泌特异性抗体又能长命的杂交瘤细胞。该技术为抗体的分子生物学研究提供了全新的手段。极大地促进了免疫学，遗传学，分子生物学的快速发展。 但传统抗体目前也面临诸多问题，如： 每使用一管新抗体都需要进行滴定测试； 多种同型对照，实验设计繁琐； 需要添加Fc阻断试剂； 抗体不佳，阳性细胞群不明显； 抗体作为细胞生物学和生物化学中最重要的试剂之一，科学界每年在这类
Human IL-2 Enzyme Immunoassay (EIA)
Interleukin-2 (IL-2) is a multi-functional protein most notably known for the ability to induce the proliferation and maturation of activated T cells. Additional biological functions include: Stimulus for the division of activated
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Interleukin-2 / IL-2抗体
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