Semaphorin 4D / SEMA4D / CD100

Semaphorin 4D / SEMA4D / CD100 Antibody Product InformationImmunogen : Recombinant Mouse Semaphorin 4D / SEMA4D / CD100 protein (Catalog#50642-M08H)

Reagents : FITC-conjugated rabbit monoclonal antibody
Clone ID : 010
Ig Type : Rabbit IgG
Concentration : 10 μl/Test, 0.1 mg/ml
Formulation : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation : This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Semaphorin 4D / SEMA4D / CD100 (rM Semaphorin 4D / SEMA4D / CD100; Catalog#50642-M08H; NP_038688.2; Met 1-Arg 733) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Semaphorin 4D / SEMA4D / CD100 Antibody Background
Semaphorin-4D, also known as SEMA4D and CD100, is a single-pass type I membrane protein which belongs to thesemaphorin family. Semaphorin-4D / SEMA4D contains oneIg-like C2-type (immunoglobulin-like) domain, onePSI domain and oneSema domain. Semaphorin-4D / SEMA4D is strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. Semaphorin-4D / SEMA4D may play a functional role in the immune system, as well as in the nervous system. Induces B-cells to aggregate and improves their viability. Semaphorin-4D / SEMA4D is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin-B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system. In the immune system, Semaphorin-4D / SEMA4D binds CD72 to activate B cells and dendritic cells. It is involved in oligodendrogenesis during development and during recovery from ischemic injury.
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