PPM1A / PP2C-alpha抗体

PPM1A / PP2C-alpha抗体产品信息免疫原 : Recombinant Human PPM1A / PP2C-alpha protein (Catalog#12984-H08E)

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 01
抗体宿主 :
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PPM1A / PP2C-alpha (rh PPM1A / PP2C-alpha; Catalog#12984-H08E; P35813-1; Met 1-Trp 382). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PPM1A / PP2C-alpha抗体 Background
Protein phosphatase 1A, also known as Protein phosphatase 2C isoform alpha, PP2C-alpha and Protein phosphatase IA and PPM1A, is a member of the PP2C family. PPM1A / PP2C-alpha is a phosphatase which dephosphorylates and inactivates a broad range of substrates, including TGF-beta, MAP kinases, p38 and JNK kinase cascades, and is involved in tumor suppression. PPM1A dephosphorylates and promotes nuclear export of TGFbeta-activated Smad2/3. Ectopic expression of PPM1A abolishes TGFbeta-induced antiproliferative and transcriptional responses, whereas depletion of PPM1A enhances TGFbeta signaling in mammalian cells. Smad-antagonizing activity of PPM1A is observed during Nodal-dependent early embryogenesis in zebrafish. PPM1A / PP2C-alpha plays a critical role in terminating TGFbeta signaling through dephosphorylation of Smad2/3. PPM1A / PP2C-alpha plays a critical role in the regulation of normal placentation by inhibiting trophoblast migration and invasion. PPM1A and to some extent PPM1B are important negative regulators of positive transcription elongation factor b (P-TEFb) function.
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