IL-1RA抗体

IL-1RA抗体产品信息免疫原 : Recombinant Human IL-1RA protein (Catalog#10123-HNAE)

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 02
抗体宿主 : Mouse IgG2b
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-1RA (rh IL-1RA; Catalog#10123-HNAE; NP_776214.1; Arg26-Glu177). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
IL-1RA抗体 Background
IL1 is an important prototypic pro-inflammatory cytokine that affects multiple cell types, often in concert with another cytokine, tumor necrosis factor (TNF). There are two forms of IL1, IL1α. and IL1β, whose function are mediated by the two specific receptors on the cell surfaces. The IL1 receptor antagonist (IL1RA), formerly called the IL1 inhibitor, is a member of the IL1 cytokine family which binds to the same receptor (IL1R) as IL1, and thus prevents IL1 from signal transduction without interaction with the IL1 molecules. In terms of protein similarities,IL1RA is more closely related to IL1β than it is to IL1α. IL1RA modulates a variety of IL1-related immune and inflammatory responses, and accordingly, the balance between IL1 and IL1Ra in local tissues plays an important role in the susceptibility to and severity of many diseases. IL1RA is suggested to have possible therapeutic applications in treatment of sepsis, rheumatoid arthritis, and chronic myelogenous leukemia. Four alternatively spliced transcript variants encoding distinct isoforms have been identified, and the isoform 1 of IL1RA is secreted from monocytes, macrophages, neutrophils, and other cells.
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