SPARCL1抗体产品信息免疫原 : Recombinant Human SPARCL1 protein (Catalog#10046-H08H)
Reagents : FITC-conjugated mouse monoclonal antibody
Clone ID : 05
抗体宿主 : Mouse IgG2b
Concentration : 10 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SPARCL1 (rh SPARCL1; Catalog#10046-H08H; NP_004675.3; Met1-Phe664) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
SPARCL1抗体 Background
SPARC-like protein 1 (SPARCL1; also known as SC1, high endothelial venule protein, or hevin) is an extracellular matrix-associated, secreted glycoprotein belonging to the SPARC (secreted protein acidic and rich in cysteine) family of matricellular proteins. It contains three conserved structural domains that are implicated in the regulation of cell adhesion, migration, and proliferation. SPARCL1 is expressed in a wide range of tissues, such as tissues of the lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon. SPARCL1 has antiadhesive properties, and loss of SPARCL1 expression is associated with increased proliferative activity and cell cycle progression. It is suggested that it may influence multiple cellular processes during distinct stages of brain development and function. SC1 may also be involved in the pathogenesis of multiple neural traumas and function as a tumor suppressor and regulator of angiogenesis, and is aberrantly expressed in brain tumors.
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