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- xy60003-MM02
- 2025年07月13日
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- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
CD4 Antibody
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
Clone ID : 02
Ig Type : Mouse IgG1
Formulation : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
Preparation : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Ferret CD4 (rF CD4; Catalog#60003-F08H; ABS50090.1; Met 1-Leu 401). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
CD4 Antibody Background
T-cell surface glycoprotein CD4, also known as T-cell surface antigen T4/Leu-3, is a single-pass type I membrane protein. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is a glycoproteinexpressed on the surface of T helper cells, regulatory T cells,monocytes, macrophages, anddendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 before being named CD4 in 1984. CD4 is aco-receptorthat assists theT cell receptor (TCR) to activate its T cell following an interaction with anantigen presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR. CD4 interacts directly withMHC class II molecules on the surface of the antigen presenting cell via itsextracellulardomain. CD4 is a primary receptor used byHIV-1to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.
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文献和实验大鼠CD4分子（CD4） 酶联免疫 分析（ ELISA ） 试剂 盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定大鼠血清，血浆及相关液体样本中 CD4分子（CD4） 含量。 实验原理 ： 本试剂盒应用双抗体夹心法测定 标本 中 大鼠 CD4分子（ CD4 ） 水平。用纯化的 大鼠 CD4分子（ CD4 ） 抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入 CD4分子（ CD4 ） ，再与HRP
CD4 分子 CD4 常用单克隆抗体或代号：T4，Leu3a 主要表达细胞：Tsub，Msub，Thysub T细胞 分子质量(kDa)和结构：gp55(IgSF) 功 能：与MCHn类分子结合，信号转导，HIV受体 CD4 Aka OKT4, T helper/inducer On chromosome #12p Nonpolymorphous
Purification of Immature CD4+CD8+ Thymocytes by Panning with Anti-CD8 Antibody
Most T lymphocytes of the immune system differentiate within the thymus along the CD4/CD8 developmental pathway by a highly ordered process termed thymic selection ( 1 , 2 ). The maturation status of thymocytes is commonly assessed
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