CD84 / SLAMF5抗体

CD84 / SLAMF5抗体产品信息免疫原 : Recombinant human CD84 protein ( Catalog #10100-H08H )

抗体类型: Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 6
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human CD84 extracellular domain ( rh CD84 ; Catalog #10100-H08H ; Met 1- Gly 225 ; NP_003865.1 ).
CD84 / SLAMF5抗体背景综述
The CD2 family receptors are type I transmembrane glycoproteins belonging to immunoglobulin (Ig) superfamily characterized by a membrane-proximal Ig constant 2 (C2) domain and a membrane-distal variable (V) domain that is responsible for ligand recognition. CD84, also known as LY9B and SLAMF5, is a homophilic member of the SLAM (signaling lymphocyte activation molecule) subfamily of the CD2 family. The SLAM family receptorsmediate signal transduction through the interaction of its ITSM (immunoreceptor tyrosine-based switch motifs) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein ) and EAT-2 ( EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. Human CD84 is expressed as a single chain on dendritic cells, monocytes, macrophages, eosinophils, mast cells, granulocytes, and platelets. As a self-ligand, only the first N-terminal Ig V domain is requisite for the homotypic CD84-CD84 interaction, and it has been demonstrated that CD84 homophilic engagement enhances TCR-induced IFN-γ secretion and induces platelet stimulation.
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