GFRA2抗体产品信息免疫原 : Recombinant Human GFRA2 protein (Catalog#10331-H08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 101
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human GFRA2 (rh GFRA2; Catalog#10331-H08H; NP_001486.4; Met 1-Ser 441).
GFRA2抗体 Background
GDNF family receptor alpha-2, also known as GFR-alpha-2, Neurturin receptor alpha, TGF-beta-related neurotrophic factor receptor 2, GFRA2, GFRα-2, and GDNFRB, is a cell membrane protein which belongs to theGDNFR family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF-beta superfamily of growth factors. Three receptors for these factors, GFRα-1, GFRα-2 and GFRα-3 have been identified. These receptors do not contain transmembrane domains and are attached to the cell membrane by GPI linkage. Both GFRα-1 and GFRα-2 have been shown to mediate the GDNF-dependent and NTN-dependent phosphorylation and activation of the tyrosine kinase Ret which is necessary for kidney and enteric neuron development. GFRα-1 is the primary receptor for GDNF and GFRα-2 exhibits a preference for NTN. GFRα-2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It can also mediate GDNF signaling through the RET tyrosine kinase receptor.
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