EpCAM / TROP-1 / TACSTD1抗体

EpCAM / TROP-1 / TACSTD1抗体产品信息免疫原 : Recombinant Mouse EpCAM / TROP-1 / TACSTD1 protein (Catalog#50591-M08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 065
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Mouse EpCAM / TROP-1 / TACSTD1 (rM EpCAM / TROP-1 / TACSTD1; Catalog#50591-M08H; NP_032558.2; Met1-Thr266).
EpCAM / TROP-1 / TACSTD1抗体 Background
Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type Itransmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. This protein is present in the majority of human epithelial cells and is highly expressed in gastrointestinal carcinomas. It has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. Since the cell-cell adhesion is known to play an important role in tumor progression and metastasis, the high expression of GA733-2 antigen is associated with malignant tumor development in various types of cancer lesions. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. EpCAM is being used as a target for immunotherapy treatment of human carcinomas.
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