SerpinF2抗体产品信息免疫原 : Recombinant Human SerpinF2 protein (Catalog#10297-H08H)
Reagents : FITC-conjugated rabbit monoclonal antibody
Clone ID : 034
抗体宿主 : Rabbit IgG
Concentration : 10 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinF2 (rh SerpinF2; Catalog#10297-H08H; NP_000925.2; Met 1-Lys 491) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
SerpinF2抗体 Background
SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily. SerpinF2 is the principal physiological inhibitor of serine protease plasmin, and as well as, an efficient inhibitor of trypsin and chymotrypsin. This protease is produced mainly by liver and kidney, and also expressed at moderate level in other tissues such as muscle, intestine, central nervous system and placenta. Alpha-2 AP is an unusual serpin in that it contains extensive N- and C-terminal sequences flanking the serpin domain. The N-terminal sequence is crosslinked to fibrin by factor XIIIa, whereas the C-terminal region mediates the initial interaction with plasmin. Alpha-2 AP plays the dominant role in inhibiting both plasma clot lysis and thrombus lysis, and accordingly, the deficiency of Alpha-2 antiplasmin in humans results in uncontrolled fibrinolysis and a bleeding disorder.
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