Uteroglobin / SCGB1A1抗体

Uteroglobin / SCGB1A1抗体产品信息免疫原 : Recombinant Human Uteroglobin / SCGB1A1 protein (Catalog#10808-H08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 030

抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human Uteroglobin / SCGB1A1 (rh Uteroglobin / SCGB1A1; Catalog#10808-H08H; P11684; Met1-Asn91).
Uteroglobin / SCGB1A1抗体 Background
Uteroglobin (UG), or Secretoglobin 1A member 1 (SCGB1A1), a protein belongs to the secretoglobin family. Uteroglobin/SCGB1A1 also known as Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10), is a small molecular weight secreted protein found only in mammals, and mainly expressed in lung, with anti-inflammatory/immunomodulatory properties. Previous in vitro studies demonstrated that CCAAT/enhancer-binding proteins (C/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression, whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with antiinflammatory / immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A (2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its antiinflammatory activities, Uteroglobin manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. The mechanism (s) of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.
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