SIGIRR / TIR8抗体

SIGIRR / TIR8抗体产品信息免疫原 : Recombinant Human SIGIRR / TIR8 protein (Catalog#12165-H08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 016
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human SIGIRR / TIR8 (rh SIGIRR / TIR8; Catalog#12165-H08H; Q6IA17-1; Met1-His118).
SIGIRR / TIR8抗体 Background
SIGIRR (single immunoglobulin IL-1 receptor-related molecule) is a member of the interleukin 1 receptor (IL-1R) superfamily, and was identified in mouse and human. Although SIGIRR shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR is a negative regulator for Toll-IL-1R signaling. It plays a critical role in gut homeostasis, intestinal inflammation, and colitis-associated tumorigenesis by maintaining the microbial tolerance of the colonic epithelium. SIGIRR-deficient colonic epithelial cells displayed commensal bacteria-dependent homeostatic defects, indicating that SIGIRR is critical in controlling the homeostasis and innate immune responses of the colon to enteric microflora. Moreover, SIGIRR-deficient mice developed stronger Th2 immune response and this discovery suggested that SIGIRR is important in the regulation of Th2, possibly through its impact on IL-33-ST2-mediated signaling.
SIGIRR / TIR8抗体相关产品如下：xy-3882R GPX1谷胱甘肽过氧化酶1
xy-3790R GM-CSF粒细胞-巨噬细胞克隆刺激因子抗体
xy-15361R GPR62G蛋白偶联受体GPR62蛋白抗体
xy-3854R GREB1乳腺癌雌激素调控蛋白GREB1抗体
xy-4720R GDF9生长分化因子9抗体
xy-2188R GAPDH 3-磷酸甘油醛脱氢酶抗体
xy-3818R GDF15生长分化因子15/巨嗜细胞抑制因子1抗体
xy-15392R GPR91G蛋白偶联受体GPR91蛋白抗体
xy-4241R GLUT8葡萄糖转运蛋白8抗体
xy-6622R Glycophorin C糖蛋白C抗体
xy-6617R GABA Transporter 1γ氨基丁酸运载蛋白1抗体
xy-6616R GATA2GATA结合蛋白2抗体
xy-4279R Growth Arrest Specific Protein 7生长休止特定蛋白7抗体
xy-8454R phospho-GluR1 (Ser836)磷酸化谷氨酸受体1抗体
xy-12025R GPR116G蛋白偶联受体116抗体
xy-4109R G protein alpha 12鸟苷酸调节蛋白12抗体
xy-5355R phospho-GFAP (Ser8)磷酸化胶质纤维酸性蛋白抗体
xy-5356R phospho-GABBR2 (Ser783)磷酸化G氨基丁酸B型受体2抗体
xy-5357R phospho-GABBR2 (Ser892) 磷酸化G氨基丁酸B型受体2抗体
xy-5720R GDF10生长分化因子10抗体（TGF-β超家族10）
xy-15369R GPCR LOC51210G蛋白偶联受体LOC51210蛋白抗体
xy-5715R GIG34细胞生长抑制蛋白34
xy-6579R Growth Hormone生长激素抗体
xy-13460R GMPPAGDP甘露糖焦磷酸化酶抗体
xy-6564R GPR171G蛋白偶联受体171抗体
xy-11847R GPM6B神经细胞膜糖蛋白M6b
xy-6247R GUK1鸟苷酸激酶GMK抗体
xy-4691R Galactocerebroside半乳糖脑苷脂酶抗体
xy-7540R GRK5G蛋白偶联受体激酶5抗体
xy-7502R GTP binding protein REM1GTP结合蛋白REM1抗体
xy-4692R phospho-GSK3 Alpha(Ser21)磷酸化糖原合酶激酶-3α抗体
xy-11461R GDF7生长分化因子7抗体
xy-7057R Glucokinase regulatory protein葡萄糖激酶调节蛋白抗体
xy-8402R GCLCγ谷氨酰半胱氨酸合成酶抗体（γ-GCSc）