Cathepsin D / CTSD抗体

Cathepsin D / CTSD抗体产品信息免疫原 : Recombinant Human Cathepsin D / CTSD protein (Catalog#12517-H08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 010
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human Cathepsin D / CTSD (rh Cathepsin D / CTSD; Catalog#12517-H08H; P07339; Met1-Leu412).
Cathepsin D / CTSD抗体 Background
Cathepsin D (CTSD) is a well known lysosomal aspartyl protease and is a member of the peptidase C1 family found in almost all cells and tissues of mammals. It has a specificity similar to but narrower than that of pepsin A. Cathepsin D/CTSD plays an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Cathepsin D/CTSD is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis, and can also induce apoptosis in presence of cytotoxic factors. However, on contrast, in certain studies an inhibitory role of CTSD in apoptosis was also reviewed. In addition, Cathepsin D/CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases.
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